Data 53, 199200 (2008), N. Sunsandee, S. Suren, N. Leepipatpiboon, M. Hronec, U. Pancharoen, Fluid Phase Equilib. This chamber is lined with cells that secrete catalases and peroxidases. 4]DYR@'c HVoLg~Z+ Hydroquinone Safety Data Sheet according to Federal Register / Vol. Then take the water and put the measurement into the microwave until boiled. Monobenzone occurs as a white, almost tasteless crystalline powder, soluble in alcohol and practically insoluble in water. If youd like my help or recipes for this bleaching cream please contact me on Instagram @kaylinell and @kay.linell or Facebook at kay linell. The experimental solubilities were correlated using two regression equations. A common route involves hydroxylation of phenol. endstream endobj 277 0 obj <>stream Hydroquinone is extensively used as a photographic developer, an antioxidant, and a stabilizing agent for readily oxidizable polymers. Cationic salts of acidic ascorbyl esters, including inorganic salts, preferably magnesium ascorbyl phosphate, and amino acyl derivatives, preferably aminopropyl ascorbyl phosphate, are preferred in this invention. Then take the water and put the measurement into the microwave until boiled. ORIGINAL CODE: 0009013, Ref document number: It is soluble in water. Editor's Rating: Tests, which results are detailed in the following two tables, are performed at 5C and 40C for certain percentages of magnesium ascorbyl phosphate at specific pHs. Toughness of the polymer increases due to the presence of flexible units in the backbone such as long chain diols (e.g., diethylene glycol, dipropylene glycol, triethylene glycol) or long chain saturated acids (e.g., adipic . and our Please sign in to view account pricing and product availability. In the environment, hydroquinone showed increased toxicity for aquatic organisms, being less harmful for bacteria and fungi. With an account you can check out faster, view your online order history and access your shopping bag or saved items from any device. uuid:3780f5dc-b322-4e29-9b1d-4c4d10b1e282 These can be burning, redness, sensitization and irritation in some patients. Natural antioxidants could replace hydroquinone derivatives used in industry. [22] The FDA stated that hydroquinone cannot be ruled out as a potential carcinogen. 4. SAS Anti-ox booster 1% 0.3g. https://doi.org/10.1007/s10765-020-02750-4, DOI: https://doi.org/10.1007/s10765-020-02750-4. Our team has been notified and we will fix it as soon as possible. Retinoids are included from about 0.01% to about 5%, preferably from about 0.025% to about 2%, more preferably 0.05% to about 1.0%, and most preferably from about 0.025% to about 0.5%. Your document download will begin shortly. This compound is gathered from the beaver's castor sacs.[35]. AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR, Kind code of ref document: The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals. [Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O, trimethyl-[phenyl-bis(trimethylsilyloxy)silyl]oxysilane, C[Si](C)(C)O[Si](O[Si](C)(C)C)(O[Si](C)(C)C)C1=CC=CC=C1, C\C(=C/C=O)\C=C\C=C(\C=C\C1=C(CCCC1(C)C)C)/C, 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine, CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/C\C=C/CCCCC, 2-[2-[2-[2-[2-[2-(2-dodecoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol, C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1, O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C, [Na+].[Na+].[Na+]. As utilized herein, the inhibition of the retinoid oxidation should be sufficient to prohibit browning of the composition for its shelf life, preferably greater than about six months, more preferably greater than about twelve months, and most preferably greater than about eighteen months. endstream endobj 382 0 obj << /Type /FontDescriptor /Ascent 891 /CapHeight 656 /Descent -216 /Flags 34 /FontBBox [ -558 -307 2034 1026 ] /FontName /BCGJCE+TimesNewRoman,Bold /ItalicAngle 0 /StemV 160 /XHeight 0 /FontFile2 389 0 R >> endobj 383 0 obj << /Type /Font /Subtype /TrueType /FirstChar 32 /LastChar 181 /Widths [ 250 0 0 0 0 0 0 278 333 333 500 0 250 333 250 278 500 500 500 500 500 500 500 500 500 500 333 333 0 570 0 0 0 722 667 722 722 667 611 778 778 389 500 778 667 944 722 778 611 778 722 556 667 722 722 1000 722 722 0 333 0 333 0 0 0 500 556 444 556 444 333 500 556 278 333 556 278 833 556 500 556 556 444 389 333 556 500 722 500 500 444 0 0 0 0 0 0 0 0 0 0 0 500 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 500 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 576 ] /Encoding /WinAnsiEncoding /BaseFont /BCGJCE+TimesNewRoman,Bold /FontDescriptor 382 0 R >> endobj 384 0 obj << /Type /FontDescriptor /Ascent 929 /CapHeight 0 /Descent -249 /Flags 32 /FontBBox [ -184 -249 1037 929 ] /FontName /BCGKAB+ImprintMT-Shadow /ItalicAngle 0 /StemV 0 /FontFile2 390 0 R >> endobj 385 0 obj << /Type /Font /Subtype /TrueType /FirstChar 32 /LastChar 122 /Widths [ 250 0 0 0 0 0 0 0 323 323 0 0 0 375 240 0 510 427 510 510 0 510 0 510 510 510 0 0 0 0 0 0 0 729 0 729 0 698 0 0 854 0 0 0 0 927 802 813 0 0 0 604 0 0 0 0 802 0 0 0 0 0 0 0 0 448 552 0 552 448 0 0 573 271 0 0 271 875 573 500 0 552 375 0 323 573 0 0 0 500 448 ] /Encoding /WinAnsiEncoding /BaseFont /BCGKAB+ImprintMT-Shadow /FontDescriptor 384 0 R >> endobj 386 0 obj << /N 3 /Alternate /DeviceRGB /Length 2575 /Filter /FlateDecode >> stream 552591, Z. Esina, M. Korchuganova, Theor. Other solubilities: soluble in alcohol and ether,slightly soluble in benzene,readily soluble in ethanol,acetone and methanol, Needle-like Crystals or Crystalline Powder. Monobenzone is the monobenzyl ether of hydroquinone used medically for depigmentation. This invention relates to methods and compositions for the treatment of pigmentation disorders, including hyperpigmentation and vitiligo. Hydroquinone is a major benzene metabolite, which is a well-known haematotoxic and carcinogenic agent associated with malignancy in occupational environments. Bioaccumulative potential Hydroquinone (123 -31 -9) Bioaccumulative potential Not established. How do I dissolve hydroquinone powder to make a 20% and 10% concentration? 420, 2429 (2016), W. E. Acree Jr, Thermochim Acta 189, 3756 (1991), F. L. Nordstrm, . C. Rasmuson, J. Chem. 0000005757 00000 n A preferred embodiment utilizes encapsulation. N')].uJr vz >I d50dwp?i4,H3. Mobility in soil No additional information available 12.5. Chem. The color stability of the hydroquinone composition is promoted by one or more antioxidants in the hydroquinone phase, preferably sulfite, including but not limited to sulfites, bisulfites, metabisulfites, their salts and their derivatives, most preferably sodium metabisulfite, and a cationic salt of acidic ascorbyl esters, most preferably magnesium ascorbyl phosphate. Antioxidants, preferably sulfites, including but not limited to sulfites, bisulfites, metabisulfites, their salts, and their derivatives, most preferably sodium metabisulfite, have been used to stabilize certain compositions, which have included hydroquinone. Have an order or account question, find answers in our Online Support articles. 0000053439 00000 n Additionally, a water-soluble antioxidant, preferably a sulfite, including but not limited to sulfites, bisulfites, metabisulfites, their salts and their derivatives, most preferably sodium metabisulfite, may be helpful in stabilizing the hydroquinone composition. A specific embodiment of the invention is listed in the following table. INCI HydroquinoneEastman Hydroquinone, USP is a skin care ingredient used to produce effective skin- lightening applications for depigmentation. Chem. Hydroquinone is sold by chemical suppliers. I made my own hydroquinone 4% and added it to my cream. Calorim. According to the polar paradox theory, this should lead to a dissolution of . Recent pieces of . Eastman has active ingredients, thickeners, plasticizers, film formers, and more for your personal care formulations. Johnson & Johnson Consumer Products, Inc. Johnson & Johnson Consumer Companies, Inc. AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR, STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN, Color Stability of 4% HQ Compositions with varying pH and % Sodium Metabisulfite at 5C and 40C, Color Stability of 4% HQ Compositions with varying pH and % Magnesium Ascorbyl Phosphate at 5C and 40C, Polyacrylamide (and) C 13-14 isoparaffin (and) laureth-7, Water, Soybean (Glycine Soja) Oil, Carnauba (Copemicia Cerifera), wax, tocopherol, retinol, Ceteareth-20, Water, Soybean (Glycine Soja) Oil, Carnauba (Copernicia Cerifera), wax, tocopherol, retinol, Ceteareth-20, Compositions for the treatment of pigmentation disorders and methods for their manufacture, Stabilization composition including hydroquinone or derivative thereof, Stabilized retinol for cosmetic dermatological, and pharmaceutical compositions, and use thereof, Depigmenting composition for the skin comprising adapalene and at least one depigmenting agent, Depigmenting composition for the skin, use of a depigmenting composition for the skin, cosmetic use of the same and method for non-therapeutic cosmetic treatment, Cosmetic designs and products using intronic RNA, Holistic composition and method for reducing skin pigmentation, Topical compositions and methods of manufacturing them in specifically treated steel vessels, System for improved percutaneous absorption of skin benefiting agents, Discontinuous surface coating for particles, Method of treating skin requiring chemical peel procedure, Method of treating skin needing hyaluronic acid treatment, Method of treating skin having incision from surgical procedures, Method of treating skin requiring hair removal procedure, Method of treating skin requiring Intense Pulse Light (IPL) procedure, Method of treating skin subject to or affected by aesthetic surgical procedures, Method of treating skin needing ablative treatment, Method of treating skin requiring radiofrequency procedure, Method of treating skin requiring non-ablative procedure, Method of treating skin requiring fractional resurfacing treatment, Method of treating skin needing botulinum toxin type a treatment, Method of treating skin requiring microdermabrasion, Method of treating skin needing collagen treatment, Method of treating skin requiring skin cancer treatment, Methods of treating skin to enhance therapeutic treatment thereof, Ras mutation and compositions and methods related thereto, Compositions, kits and regimens for the treatment of skin, especially dcolletage, Calcium sequestration compositions and methods of treating skin pigmentation disorders and conditions. Protected retinoid may be added to these compositions for additional skin benefit effects. Provided by the Springer Nature SharedIt content-sharing initiative, Over 10 million scientific documents at your fingertips, Not logged in 38, 40814091 (1999), J. Qingzhu, M. Peisheng, Y. Shouzhi, W. Qiang, W. Chang, L. Guiju, J. Chem. [23] This conclusion was reached based on the extent of absorption in humans and the incidence of neoplasms in rats in several studies where adult rats were found to have increased rates of tumours, including thyroid follicular cell hyperplasias, anisokaryosis (variation in nuclei sizes), mononuclear cell leukemia, hepatocellular adenomas and renal tubule cell adenomas. This is a preview of subscription content, access via your institution. Availability. I'd like the consistency to be thin like a gel so that it absorbs quicker. All Rights Reserved, View All Eastman Hydroquinone USP Articles. [32], Hydroquinone is thought to be the active toxin in Agaricus hondensis mushrooms. Since hydroquinone has a tendency to discolor through oxidation, these antioxidants are used because they have greater tendencies to oxidize than hydroquinone. Read our Privacy Notice. It exerts a depigmenting effect on skin of mammals by increasing the excretion of melanin from the melanocytes. Eng. Free format text: HYdroquinone can be found in various skin care products. Other properties of hydroquinone are given in Table 1. Substituted derivatives of this parent compound are also referred to as hydroquinones. 108. Thermodyn. Hydroquinone is highly susceptible to ring substitution by Friedel-Crafts reactions such as alkylation. The method of item 1 07 wherein the hydroquinone is present in about 4%. AzA inhibits tyrosinase. Anal. HyTSwoc [5laQIBHADED2mtFOE.c}088GNg9w '0 Jb Determination and Correlation of Solubilities of Benzoic Acid, Salicylic Acid, Resorcinol and Hydroquinone in Water and in 1-Octanol at Temperatures from 297.25K to 334.45K. Thermodyn. Table I shows that at 5C, 4% hydroquinone compositions maintain their white color with the addition of at least about 0.01% sodium metabisulfite at the low pH ranges (from about 3.50 to about 5.50) and at least 0.05% sodium metabisulfite for pH about 6.0 to about 7.0. Methylaminophenol, used in photography, is produced in this way:[8]. We have found that a cream containing 5% of hydroquinone and 0.05 % of laevo-ascorbic acid remains white, and the emulsion remains unbroken after many months of storage, The laevo-ascorbic or cevitamic acid is pr'eferably employed in the free condition; but if desired, the salts, and especially the water-soluble salts thereof, may be employed . Examples of suitable methods of encapsulation include encapsulation by liposomes, wax, paraffin or any material or combination of materials which protect the retinoid from exposure to oxygen and inhibit oxidation of the retinoid from oxidation. Other properties of hydroquinone are given in Table 1. 0000002544 00000 n Preferably, the protected retinoid, in particular retinoic acid, retinal, and their derivatives, isomers and analogs (such as adapalene, tazarotene and isotretoin), is in the form of small beads or spheres suitable for incorporation into a topical composition. Some documentation and label information may refer to the legacy brand. Polysorbate 20 0.5% 0.15g. 0000002585 00000 n A3, Free format text: Since the neutral pH of the hydroquinone composition with sodium metabisulfite and magnesium ascorbyl phosphate is preferably from about 5.5 to about 8.0, more preferably a pH of from about 5.5 to about 7.5, and most preferably at a pH of from about 6.0 to about 7.5, the pH is acceptable for also including retinoids in the composition. The composition is preferably formulated in separate phases as designated below. 15, 188196 (1996), U. Domaska, Fluid Phase Equilib. . Stir until uniform. HYdroquinone can be found in various skin care products. Best Budget Hydroquinone Cream Ambi Skincare Fade Cream (56g/2oz) View on Amazon. Chem. 2y.-;!KZ ^i"L0- @8(r;q7Ly&Qq4j|9 1 Solubility data for compounds that ordinarily are liquids at 25 are expressed in terms of the ratio of the volume of solute to the volume of solvent; i.e., 1 mL dissolved in mL of solvent. 230, 176183 (2005), A. Apelblat, E. Manzurola, N. A. Balal, J. Chem. The process of making a stable hydroquinone composition having a pH of about 5.5 to about 8.0 comprising: combining the following ingredients, in a carbon dioxide atmosphere: first, magnesium ascorbyl phosphate and sodium metabisulfite, then, third, magnesium ascorbyl phosphate, then, Application filed by Medicis Pharmaceutical Corp, [H]O[C@@]([H])(C([H])([H])O*)[C@@]1([H])OC(=O)C(O*)=C1O*, OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C, 3-aminopropyl [(2R)-2-[(1S)-1,2-dihydroxyethyl]-3-hydroxy-5-oxo-2H-furan-4-yl] hydrogen phosphate, NCCCOP(O)(=O)OC1=C(O)[C@@H]([C@@H](O)CO)OC1=O, OC(=O)C=C(C)/C=C/C=C(C)C=CC1=C(C)CCCC1(C)C, OC(=O)/C=C(\C)/C=C/C=C(C)C=CC1=C(C)CCCC1(C)C, trisodium;[(5R)-5-[(1S)-1,2-dihydroxyethyl]-2-oxido-4-oxofuran-3-yl] phosphate, [Na+].[Na+]. Hydroquinone Revision Date 24-Dec-2021 General Advice If symptoms persist, call a physician. Glycerol and citric acid, non-toxic and renewable reagents, were crosslinked by a melt polymerization reaction at temperatures from 90-150C. There are various other uses associated with its reducing power. Have an order or account question? It is also used to prepare 2% bleaching creams and certain intermediates for the synthesis of dyes, and it has some activity as an antitumoragent. Privacy Policy. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. 77, No. [21][25][23] NTP evaluation showed some evidence of long-term carcinogenic and genotoxic effects[26], While hydroquinone remains widely prescribed for treatment of hyperpigmentation, questions raised about its safety profile by regulatory agencies in the EU, Japan, and USA encourage the search for other agents with comparable efficacy. You can expect to hear back from a ChemPoint product specialist within 1 business hour. The solubilities of benzoic acid, salicylic acid, resorcinol and hydroquinone in water and in 1-octanol were measured by the dynamic method which is also called the synthetic method from 297.25 K to 334.45 K. Using differential scanning calorimetry (DSC Q2000 and SDT Q600), the melting temperature and the enthalpy of fusion of these solutes were determined. The Beaver: Its Life and Impact. I did that by using 1 cup of cream, 4tbsp of hydroquinone and 4tbsp of water or solvent. wG xR^[ochg`>b$*~ :Eb~,m,-,Y*6X[F=3Y~d tizf6~`{v.Ng#{}}jc1X6fm;'_9 r:8q:O:8uJqnv=MmR 4 Adobe Acrobat 10.1.6 Paper Capture Plug-in n3kGz=[==B0FX'+tG,}/Hh8mW2p[AiAN#8$X?AKHI{!7. and solubility in water. Gerhard Franz, Roger A. Sheldon "Oxidation" in. HYPERPIGMENTARY STAIN ELIMINATING CREAM FOR FACE SKIN AND ITS USE. Stir until uniform. Do not put this product in the microwave. endstream endobj 1 0 obj <> endobj 2 0 obj <> endobj 12 0 obj <>stream 0000002379 00000 n 65, 5786 (1998), Y.-H. Zhang, Trends Analyt. 38, 565571 (2006), K. Carlsson, B. Karlberg, Anal. Chem. M1 and M2 microemulsions contain ethanol as co-surfactant. GHS H Statement: Causes serious eye damage.Suspected of causing genetic defects.May cause an allergic skin reaction.Suspected of causing cancer.Harmful if swallowed.Very toxic to aquatic life. Approximate Solubilities of USP and NF Articles, methanol, 13; ethyl acetate, >10,000; hexanes, >10,000, 0.1 N hydrochloric acid, 1; 0.1 N sodium hydroxide, 1, boiling alcohol, 50; boiling chloroform, 80; acetone at 50, methanol, 3; isopropanol, 69; benzene, 2500; petroleum ether, 5000, dimethylformamide, 10; 10 N sodium hydroxide, 3.5, dimethylacetamide, 2; dimethylformamide, 3.5; dimethylsulfoxide, 3.5, 0.1 N hydrochloric acid, 2500; 0.1 N sodium hydroxide, 100, isopropyl alcohol, 4; propylene glycol, 9; methanol, 5.3, isopropyl alcohol, 1408; propylene glycol, 119; methanol, 75, alcohol solution (1 in 2), 2; diethylphthalate, <1; benzyl benzoate, <1, acetone, 100; methanol, 1000; 0.1 N hydrochloride acid, >1000, absolute alcohol, 8; methanol, 8; propylene glycol, 19, pyridine, 10; methanol, 71; acetone, 130; methylene chloride, 286; toluene, 2000; dioxane, 2000, carbon disulfide, 2 (slowly and usually incompletely), carbon disulfide, 2 (slowly and usually incompletely) olive oil, 100, methylenedichloride, 43; 4-methyl-2-pentanone, 100. Antioxidants in the hydroquinone phase and inorganic or amino acyl cationic salts of acidic ascorbyl esters, preferably sodium metabisulfite and magnesium ascorbyl phosphate respectively, are effective in stabilizing such hydroquinone compositions, which are used in treatment of pigmentation disorders. This page was last modified on 19 June 2019, at 20:05. 0000004433 00000 n This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. I can't use water because I cannot dissolve enough Hydroquinone into it to reach the desired concentration. NR 1L~tyj|ZZ3]jFlszH#bd]="nVj =rBF-=Y?Pe 3(\[3;wR-+7Fn ~pSQ(Rpiw^zYr''t@\vobE]u'C}io0q;^k5C@|zZNNA>,XOrztV;qO*w:MC$OI\_$Io 'v [ Formula of hydroquinone is . Hydroquinone | C6H4(OH)2 or C6H6O2 | CID 785 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities . The solubility of sodium phenytoin in binary mixtures of ethanol +water at 298.2, 303.2, 308.2 and 313.2 K was measured. 0000000731 00000 n Solubility of Hydroquinone. [17], An important reaction is the conversion of hydroquinone to the mono- and diamine derivatives. An improvement in the color stability of the 4% hydroquinone compositions is seen at and above 2.0% magnesium ascorbyl phosphate in the 6-7 pH range. 388, 7381 (2010), H. Li, G. Hu, F. Guo, L. Zhao, J. Zhu, Y. Zhang, Can. : Metabolism and disposition of hydroquinone in Fischer 344 rats after oral or dermal administration. Solubility: Moderately soluble in water, glycerin, propylene glycol, and highly soluble in ethanol Features & Benefits Can work in conjunction with glycolic acid to help reduce pigment in melasma Non-GMO Extremely low vapor pressure USP Grade European Pharma Grade Drug master file available upon request Applications The solubilities of benzoic acid, salicylic acid, resorcinol and hydroquinone in water and in 1-octanol were measured by the dynamic method which is also called the synthetic method from 297.25K to 334.45K. Using differential scanning calorimetry (DSC Q2000 and SDT Q600), the melting temperature and the enthalpy of fusion of these solutes were determined. We will respond to you shortly. It is moderately soluble in water and highly soluble in alcohol. Water Solubility 73000 mg/L at 25C 2.6B pH pKa 4.0 - 4.7 pK1 = 9.9 2.12 Oxidation:Reduction Potential +286 mV at 25C and pH 7 ENVIRONMENTAL FATE/BIODEGRADATION The most preferred example of such an antioxidant is sodium metabisulfite. hydroquinone, 1,4-benzenediol, quinol, 1,4-dihydroxybenzene, p-benzenediol, 4-hydroxyphenol, p-hydroquinone, p-hydroxyphenol, p-dihydroxybenzene, benzoquinol, Electrophoresis, Western Blotting and ELISA, Chromatography and Mass Spectrometry Reagents, Laboratory Syringe Needles and Accessories, Lab Coats, Aprons, and Other Safety Apparel, Sharps Disposal Containers and Accessories, Classroom Laboratory Supplies and Consumables, Applied Biosystems TaqMan Assay and Arrays Search Tool, Applied Biosystems TaqMan Custom Assay Design Tools, Applied Biosystems Custom qPCR Primers and TaqMan Probes Tool, Chemical Storage and Management Resource Center, Solubility in water: 70g/L in water (20C). Hydroquinone is soluble in alcohol solvents such as ethanol and methanol [17]. Data 53, 12781282 (2008), A. The combined nearly ideal binary solvent (NIBS)-Redlich-Kister equation is . Variations in pH have proven to result in excessive discoloration ranging from brownish to black. 322, 4855 (2012), K. Tamura, T. Kasuga, T. Nakagawa, Fluid Phase Equilib. While patients suffer from pigmentation disorders, they may also suffer from other skin disorders and signs of aging, including but not limited to rough skin texture, mottled pigmentation, sallow complexion, lines and wrinkles. 57, 295300 (2013), R. F. Pires, M. R. Franco Jr, Fluid Phase Equilib. A method of stabilizing a hydroquinone composition, comprising hydroquinone and one or more protected retinoids, comprising: maintaining pH of the composition at about 5.5 to about 8.0. J. The solubility in water is 6.72g/L.
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