[2] If you miss a dose, take it as soon as you remember. This medicine is available only with your doctor's prescription. Does Isosorbide Mononitrate interact with other drugs you are taking? Are you looking for information on isosorbide dinitrate (Isordil) instead? What conditions does Isosorbide Mononitrate treat? If you have recently had a head injury or a heart attack. Cao HY, Wu HD, Song ZK, Tang ML, Yang S, Liu Y, Qin L. Pan Afr Med J. Other medications may be prescribed by your doctor for these conditions. What You Need to Know, Angina (a specific type of chest pain) caused by heart disease. Contact your doctor immediately if you experience any of the following: The following side effects may get better over time as your body gets used to the medication. information submitted for this request. Tolerance is more likely to happen if you don't take your dose at the same time every day. https://naturalmedicines.therapeuticresearch.com. https://naturalmedicines.therapeuticresearch.com. Isosorbide mononitrate (Monoket) may interact with certain medications or supplements. Isosorbide mononitrate (Monoket) is available as both a immediate-release (IR, short-acting) and extended-release (ER, long-acting) tablet. PMC Never give it to other people even if their condition appears to be the same as yours. A total of 195 drugs are known to interact with isosorbide mononitrate: A total of 330 drugs are known to interact with aspirin: A total of 239 drugs are known to interact with nitroglycerin: No known alcohol/food interactions. If you have any questions about this medicine ask your pharmacist. Can cause dizziness, especially when you change positions, Interacts with erectile dysfunction medications. To use the sharing features on this page, please enable JavaScript. It works more slowly and lasts for about 12 hours, so you only need to take it once a day. Please see a good cardiologist, get admitted, get checked thoroughly. Natural Medicines. flushing - try to cut down on coffee, tea and alcohol because they can make flushing worse. 2017; doi:10.1016/j.jacc.2016.11.078. GoodRx works to make its website accessible to all, including those with disabilities. Isosorbide mononitrate helps to prevent angina chest pain from developing. information and will only use or disclose that information as set forth in our notice of Zhonghua Yi Xue Za Zhi (Taipei). Tell your pharmacist what products you are using, and ask how to use them safely (especially cough-and-cold products, diet aids, or NSAIDs such as ibuprofen/naproxen). https://naturalmedicines.therapeuticresearch.com. Nitrates in the management of acute coronary syndrome. In the US - Call your doctor for medical advice about side effects. tell your doctor if you may be dehydrated, if you have recently had a heart attack, or if you have or have ever had heart failure, low blood pressure, or hypertrophic cardiomyopathy (thickening of the heart muscles). It is used to treat and prevent a wide range of different conditions. Use of herbal products and potential interactions in patients with cardiovascular diseases. It does not have such side effects. The list below does not include all possible drug interactions with isosorbide mononitrate (Monoket). Please note that only the generic name of each medication is listed below. Isosorbide comes as a tablet, an extended-release (long-acting) tablet, and an extended-release capsule to take by mouth. Duplication for commercial use must be authorized by ASHP. https://naturalmedicines.therapeuticresearch.com. Making any changes without doctor's advice can be dangerous. We comply with the HONcode standard for trustworthy health information. Mayo Clinic on Incontinence - Mayo Clinic Press, NEW The Essential Diabetes Book - Mayo Clinic Press, NEW Ending the Opioid Crisis - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press. Store it at room temperature and away from excess heat and moisture (not in the bathroom). health information, we will treat all of that information as protected health It will not treat an angina attack that has already begun. Nitroglycerin works very quickly to widen your blood vessels and help your heart pump blood during a heart attack. Includes Isosorbide Mononitrate indications, dosage/administration, pharmacology, mechanism/onset/duration of action, half-life, dosage forms, interactions, warnings, adverse reactions, off-label uses and more. Higher than recommend dosage of sublingual isosorbide dinitrate for treating angina pectoris: a case report and review of the literature. Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. Talk to your provider if you continue to feel dizzy or have a fast heart rate a week after starting isosorbide mononitrate (Monoket). Good at preventing chest pain caused by heart disease, Available as a generic version, making it less expensive, Long-acting version only needs to be taken once daily, Short-acting tablets have to be taken on a very specific schedule for the medication to work best. 41% of reviewers reported a positive effect, while 50% reported a negative effect. Isosorbide mononitrate (Monoket) is available as a generic medication and may be significantly cheaper compared to the brand version. While both isosorbide mononitrate (Monoket) and nitroglycerin (Nitrostat) are both nitrate vasodilators, they are not the same medication. Egton Medical Information Systems Limited. See also: nitroglycerin side effects in more detail. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. View more. Clin Res Cardiol. Breastfeeding:There is data that nitrates are excreted in breast milk and may cause methemoglobinemia in infants. Try our Symptom Checker Got any other symptoms? Weight Loss for Health and Longevity, Science Reveals How Red Meat Harms the Heart, Flavored Vapes Still in Stores Despite Federal Ban, New COVID Antiviral Pills: What You Need to Know, Dr. Whyte's Book: Take Control of Your Cancer Risk, WebMD Loses Cherished Leader Kristy Hammam, Health News and Information, Delivered to Your Inbox, List Isosorbide Mononitrate side effects by likelihood and severity. Isosorbide tablets are also used with other medications to treat heart failure. The https:// ensures that you are connecting to the Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. Natural Medicines. Although not all of these side effects may occur, if they do occur they may need medical attention. Do infrared saunas have any health benefits? Patient aims to help the world proactively manage its healthcare, supplying evidence-based information on a wide range of medical and health topics to patients and health professionals. Isosorbide mononitrate is used to prevent angina (chest pain) caused by coronary artery disease (heart disease). 2021 May 11;39:28. doi: 10.11604/pamj.2021.39.28.22180. The .gov means its official. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Some of these interactions can be life-threatening. May also be prescribed off label for Esophageal Spasm. Enter other medications to view a detailed report. Please upgrade your browser or download modern browsers from here! Some products have ingredients that could worsen your heart failure. 45, Migranal), ergoloid mesylates (Hydergine), ergotamine (in Cafergot, in Migergot), methylergonovine (Methergine), methysergide (Sansert; no longer available in the U.S.), and pergolide (Permax; no longer available in the U.S.); medications for high blood pressure, heart failure, or an irregular heartbeat. This medication belongs to a class of drugs known as nitrates. . In: Textbook of Natural Medicine. There are 195 drugs known to interact with No, that's not true all the time. Seek alternatives to the CYP3A4 substrate when possible. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.AvanafilRiociguatSildenafilTadalafilVardenafil. It works to relax your blood vessels. https://naturalmedicines.therapeuticresearch.com. View interaction reports for isosorbide mononitrate and the medicines listed below. Dehydration in Buspar, how severe and when it was recovered? In case of overdose, call the poison control helpline at 1-800-222-1222. View World Anti-Doping Agency classifications, Prevention of Thromboembolism in Atrial Fibrillation, Prosthetic Heart Valves - Thrombosis Prophylaxis, Prosthetic Heart Valves - Mechanical Valves - Thrombosis Prophylaxis, Revascularization Procedures - Prophylaxis. It works by relaxing and widening blood vessels so blood can flow more easily to the heart.This medication will not relieve chest pain once it occurs. Accessed Sept. 7, 2022. For these reasons, before you start taking isosorbide mononitrate it is important that your doctor knows: Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. Mehta D. Herbal & dietary supplements. Does Viagra add to the risks of melanoma? Then, there was a two-week placebo washout, after which the alternative treatment was given. No you may not. if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking isosorbide. The two dosage regimens were equally efficient for the relief of angina pectoris without development of tolerance. If it is within 2 hours of the next dose, skip the missed dose. It is also important information to carry with you in case of emergencies. If you notice any other effects, check with your healthcare professional. This information is aggregated and used to produce personalized reports that patients can reference. Usually avoid combinations; use it only under special circumstances. Truven Health does not assume any responsibility or risk for your use of the Truven Health products. Lyrica and Metoclopramide drug interaction, Calcitriol and Metoclopramide drug interaction. As precautionary measure, it is preferable to avoid the use of isosorbide mononitrate during pregnancy. Does isosorbide mononitrate (Monoket) affect your kidneys? Bauer B (expert opinion). This branded product is no longer on the market. Cleophas TJ, Niemeyer MG, Zwinderman AH, van der Wall EE. To provide you with the most relevant and helpful information, and understand which A very serious allergic reaction to this drug is rare. Is not subject to the Controlled Substances Act. Properly discard this product when it is expired or no longer needed. These headaches may be a sign that the medication is working as it should. Some conditions may become worse when the drug is suddenly stopped. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Alcohol will increase the risk of you experiencing side-effects such as feeling dizzy and light-headed. This does not necessarily mean no interactions exist. Headache and weakness of left side (both arm and leg) may suggest a brain pathology. The narrowing makes it more difficult for blood to flow to your heart muscle. Do not change the dosing times unless directed by your doctor. Nitrates, although important for the management of angina pectoris, cause significant headache in many patients. Take this medication by mouth as directed by your doctor, usually twice a day. It is best not to drink alcohol while you are on isosorbide mononitrate. Receive price alerts, news, and other messages from GoodRx about isosorbide mononitrate (Monoket) and other healthcare topics and relevant savings offers. View all Isosorbide-5-mononitrate ISMN usually begins acting within 30 minutes and its effects last six to eight hours. What should I know about storage and disposal of this medication? This is so your doctor can check on your progress. To avoid this, if you are taking more than one dose a day, your doses may not be prescribed at equal intervals throughout the day. Isosorbide (C6H10O4), also called D-Isosorbide dinitrate, is a bio-product sourced from starch. Consult your doctor for more details. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Your health care provider and pharmacist can help you stay away from unsafe interactions. It is usually caused by narrowing of your coronary arteries due to a build-up of a fatty substance called atheroma. B complex. [2] It can be used both to treat and to prevent heart-related chest pain; however, it is generally less preferred than beta blockers or calcium channel blockers. tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. Danshen can interact strongly with some heart medicines, such as: Evening primrose may raise your risk of bleeding if you also take a blood thinner, such as: Garlic may raise your risk of bleeding if you also take a blood thinner, such as: Ginkgo biloba may raise your risk of bleeding if you also take a blood thinner, such as: If you take ginseng with warfarin, it may lessen how well warfarin works. Your provider might temporarily have you stop isosorbide mononitrate (Monoket) if this happens. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Disclaimer. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Isosorbide mononitrate helps to prevent angina chest pain from developing. Patients were randomized to either 60 mg 5-ISMN once daily (od) for two weeks or . Although unlikely, when this medication is used for a long time, it may not work as well and may require different dosing. My cardiologist recommended I get on metropolol. Mayo Clinic. Isosorbide mononitrate should not be used in patients with severe anaemia, severe hypotension, closed angle glaucoma or severe hypovolaemia.Isosorbide mononitrate may give rise to postural hypotension and syncope in some patients. Talk to your doctor if you are using marijuana (cannabis). Important information about all medicines, Notes on Isosorbide mononitrate dose and side-effects info, https://patient.info/medicine/isosorbide-mononitrate-elantan-imdur-isotard-monomax-tardisc-xismox, Manufacturer's PIL, Isosorbide mononitrate 10 mg tablets, Carmil XL; Chemydur XL; Elantan LA; Imdur; Isib XL; Ismo; Isodur XL; Isotard XL; Modisal XL; Monomax SR; Monomil XL; Nyzamac SR; Relosorb XL; Tardisc XL; Trangina XL; Xismox XL; Zemon XL, Tablets, modified-release (longer-acting) tablets, and modified-release (longer-acting) capsules, Ask your doctor or pharmacist to recommend a suitable painkiller. If you do not remember until your next dose is nearly due, then leave out the forgotten dose and take your next dose when it is due. Take isosorbide exactly as directed. Mayo Clinic; 2021. You may report side effects to the FDA at 1-800-FDA-1088. Unable to load your collection due to an error, Unable to load your delegates due to an error. tell your doctor if you are taking or have recently taken riociguat (Adempas) or a phosphodiesterase inhibitor (PDE-5) such as avanafil (Stendra), sildenafil (Revatio, Viagra), tadalafil (Adcirca, Cialis), and vardenafil (Levitra, Staxyn). Be sure to follow your provider's instructions about when to take isosorbide mononitrate (Monoket). Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. For details see our conditions. Therefore, oral nitrates should not be used by patients who are sensitive to the effects of hypotension, such as those with pre-existing hypotension, shock, vascular collapse or significant cerebrovascular disease, significant anaemia or hypothyroidism. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. If you forget to take a dose, take it as soon as you remember. You can start a phase IV clinical trial to monitor Isosorbide mononitrate safety and effectiveness. Taking erectile dysfunction medications or drinking alcohol while taking isosorbide mononitrate (Monoket) can cause your blood pressure to get dangerously low, which can be life-threatening. Click here for an email preview. What is the difference between the immediate-release (IR) and extended-release (ER) versions of isosorbide mononitrate (Monoket)? You may opt-out of email communications at any time by clicking on URL of this page: https://medlineplus.gov/druginfo/meds/a682348.html. Both versions of isosorbide mononitrate (Monoket) contain the same active ingredient. from the best health experts in the business. These products are provided 'AS IS' and 'as available' for use, without warranties of any kind, either express or implied. If you suffer headaches when taking Isosorbide mononitrate, be patient. These side effects may go away during treatment as your body adjusts to the medicine. This is a condition where the heart does not beat as efficiently as it should. It is particularly important that you tell your doctor if you are using any medicines to help treat erectile dysfunction. You may report side effects to Health Canada at 1-866-234-2345. It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. See the full pregnancy warnings document. 2023 eHealthMe.com. 1996 Dec;3(12):802-806. doi: 10.1097/00045391-199612000-00003. Copyright, 2023. Sept. 26, 2022. Am J Ther. Natural Medicines. Trapidil is as effective as isosorbide-dinitrate for treating stable angina pectoris: a multinational, multicenter, double-blind, randomized study. See also: aspirin side effects in more detail. Garlic. ask your doctor about the safe use of alcoholic beverages while you are taking isosorbide. The tablet usually is taken two or three times daily. Review/update the Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Try to keep your regular appointments with your doctor. Laboratory and/or medical tests (such as blood pressure) should be performed periodically to monitor your progress or check for side effects. Accessed Sept. 7, 2022. It might help to take isosorbide mononitrate and dinitrate after meals. Does isosorbide mononitrate (Monoket) lower blood pressure? 2023 Lybrate, Inc. All rights reserved. Healthcare data is obtained from a number of sources including the Food and Drug Administration (FDA). I took this for 4 days, and my headaches were unbearable. This side-effect usually disappears after a few days, Do not drive and do not use tools or machines while affected, If either of these becomes troublesome, speak with your doctor. Data were assessed for carryover and time effects. Store at room temperature away from light and moisture. Yet significantly fewer patients had headache on low dosage than on high dosage (45 vs 57, P < 0.02). Isosorbide mononitrate works in two ways. Your doctor may decide not to treat you with this medication or change some of the other medicines you take. Instead, the best way to dispose of your medication is through a medicine take-back program. If concomitant therapy cannot be avoided, monitor clinical effects of the . Isosorbide mononitrate is a nitrate-class drug used for the prophylactic treatment of angina pectoris; that is, it is taken in order to prevent or at least reduce the occurrence of angina. Classes: Nitrates, Angina Print Dosing & Uses AdultPediatricGeriatric Dosage Forms & Strengths tablet 10mg 20mg. This site complies with the HONcode standard for trustworthy health information: verify here. Almost 70% of older adults use them. Ask your doctor before using aspirin together with alcohol. Before taking this medication, tell your doctor or pharmacist if you are allergic to it; or to similar drugs (such as isosorbide dinitrate, nitroglycerin); or if you have any other allergies. Do not store in the bathroom. It works by relaxing the blood vessels so the heart does not need to work as hard and therefore does not need as much oxygen. All rights reserved. Call your doctor if you have any unusual problems while you are taking this medication. Your body can get used to isosorbide mononitrate (Monoket), and the same amount of medication might no longer work as well as it used to. In: Current Medical Diagnosis & Treatment 2022. government site. Isosorbide mononitrate 30% immediate-release 70% sustained-release formulation: a review. daily and increasing to 40 mg three times daily as necessary, given at 8 AM, 1 PM, and 6 PM), isosorbide mononitrate (starting at 30 mg/day in the morning and increasing to 120 mg/day as necessary), or a transdermal. Isosorbide immediate-release tablets are used for the management of angina (chest pain) in people who have coronary artery disease (narrowing of the blood vessels that supply blood to the heart).
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